WP1

Project coordination and management
Leader: UPF
Overall project coordination, scientific and technical oversight, ensuring correct execution.

WP2

Data management, curation, and quality control (RDT)
Leader: Merck KGaA
Collection, curation, and standardisation of repeated-dose toxicology study data.

WP3

Extension to studies other than systemic toxicity
Leader: BASF SE
Application of the Virtual Control Group (VCG) concept to additional types of animal studies.

WP4

Digital histopathology of control animals
Leader: Novartis
Integration of digital histopathology images into VCGs.

WP5

IT System development
Leader: grit42
Design, development, and maintenance of the VICT3R data platform.

WP6

VCG characterisation and generation (statistics)
Leader: Roche
Development and implementation of statistical methods for VCG creation and validation.

WP7

Synthetic VCGs by AI
Leader: Barcelona Supercomputing Center
Use of AI approaches to generate synthetic VCGs and address data gaps.

WP8

Retrospective and prospective testing for qualification
Leader: Roche
Evaluation of VCGs through comparison with traditional control groups.

WP9

Regulatory interaction & certification of tools (CSV GLP – OECD 17)
Leader: Syncwork
Compliance with GLP standards and engagement with regulatory authorities for VCG acceptance.

WP10

Dissemination and sustainability
Leader: SYNAPSE
Communication of project results, sustainability planning, collaboration with related initiatives, and training activities.